By integrating three innovative technologies of single-cell multi-omics, genome editing, and machine learning, we aim to address the following three research questions:

  1. What are the genetic and molecular drivers of phenotypic heterogeneity across cells, organs, individuals, and species?
  2. How does the collective behavior of a community of cells emerge from the behavior and cellular interactions of individual cells?
  3. What are the roles of cellular heterogeneity in the collective behavior of organs or individuals across environments, diseases and species?